Interpol said it has issued Red Notices for the arrests of ousted Libyan leader Moammar Gadhafi, his son Saif and former intelligence chief Abdullah al-Senussi.
The action Friday came after Prosecutor Luis Moreno-Ocampo of the International Criminal Court at The Hague requested arrest warrants for the three.
Red Notices will be sent to all of Interpol's 188 member countries and include essential identifying and judicial information.
A Red Notice requests the arrest of a wanted person, with a goal of extradition.
"Prosecutor Moreno-Ocampo's request for Interpol Red Notices will significantly restrict the ability of all three men to cross international borders," said Ronald K. Noble, Interpol secretary-general.
Gadhafi's whereabouts remained a mystery after reports he was surrounded in the Sahara Desert or heading to neighboring Niger.
Interim Libyan Prime Minister Mahmoud Jibril declined to discuss where Gadhafi might be hiding, the BBC reported.
Gadhafi loyalists in the town of Bani Walid, southeast of the capital of Tripoli, were given until Saturday to lay down their arms or face military force.
Two of Gadhafi's sons and some of his senior aides may be there, the BBC said.